Sensing · Understanding · Connecting
We transform everyday Parkinson's experience into continuous clinical insight.
The Invisibility of the Everyday
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Emerging Symptoms
Subtle clinical signals pass completely undetected between spaced episodic checkups.
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Guesswork Adjustments
Crucial medication revisions rely heavily on subjective and fuzzy patient recollection.
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Lost Track Records
Nuanced patient deterioration indices fail to clear clinical filters into the medical records.
Turn Everyday Life Into Diagnosis
Entwine captures and translates structural patient signals continuously. A change in voice, a lingering pause before a sentence, or an anomalous behavioral signal becomes measurable, high-fidelity clinical data.
One System. Three Layers of Value.
Lived experience flows into our always-present AI companion ("Lucy"). Highly structured, distinct intelligence flows out across every core stakeholder vector.
- Voice patterns
- Sleep & circadian rhythms
- Narrative & dreams
- Mood & cognition
- Movement
- Self-Agency — Patient
- Applied Intelligence — Physician
- Discovery — Researcher
Self-Agency
Unlocks continuous self-understanding, giving individual patients the tools to map and interpret their daily conditions accurately.
Applied Intelligence
Empowers clinical specialists to look directly past brief, isolated visits into objective real-world context parameters.
Discovery Metrics
Aggregates deep hidden digital phenotypes to map complex behavioral disease variations for fast-tracked molecule exploration.
Predicting the Transition Before the Decline
Most Parkinson's care reacts to OFF states after they happen. Entwine identifies the transition leading into them.
Stay out of the way.
Lucy is an active participant. The system observes and learns.
Recognize the moment.
A gentle, personalized intervention. A walk. Medication. A friend to call.
Support, don't instruct.
Lucy is attuned to needs and requests. No predetermined recipe. The patient is met where they are.
The same mechanism may extend beyond motor states — into cognition, mood, energy, and social behavior.
See the Patient Between Visits
Most care is based on brief visits and semi-subjective recall. Entwine provides continuous visibility.
A continuous patient story
Signals become longitudinal insights.
Decisions based on patterns
Not isolated snapshots.
No more reconstructed recall
Arrive prepared. Act with clarity.
- Motor fluctuations: 14 OFF episodes/wk (↑ from 9)
- Voice hesitation: 18% increase over 87d
- Sleep continuity: stable
- Narrative themes: medication anxiety, work disclosure
Designed in collaboration with movement-disorder clinicians.
The Connective Tissue
Entwine forms the direct bridge between data silos and lived human experience. This team operates as the core execution muscle.
Strategic builder connecting technology, ecosystems, and human experience.
Pediatric pulmonologist, healthcare innovator, incubator co-founder.
Dean of Students, accessibility expert, creative strategist.
Entwine is built between worlds. This team is the connective tissue.
Advisory Board
Prof. Avraham Hershko
Prof. David Arkadir
